cannabinoide rezeptoren und das Endocannbinoid system des menschen
Cannabinoids Receptors
February 24 -2018

Cannabinoids Receptors – Definition & Effects on the Body

Cannabinoids Receptors – wondering what are these? We’ve already explained what Cannabinoids are. Today we talk about their receptors. In this article, we explain even more. Like: What cannabinoids receptors do to your body? Rather cannabinoids are legal or not? Finally interesting, how cannabinoids can show in a drug test. Furthermore, we answer all your questions related to Cannabinoids Receptors. So let’s start with this article.

What are Cannabinoids Receptors?

Cannabinoid Receptors enlarged
CB1 and CB2 enlarged

First of all, the endogenous cannabinoid system is part of our nervous system. As its name indicates, it is coming from the active compounds of the cannabis plant.

The knowledge about cannabinoid receptors is still very young. So far, distinctions made between CB1 and CB2 cannabinoid receptors. Also, researchers have discovered that there are also endocannabinoids in this system.

What types of cannabinoid receptors are there?

Cannabinoids activate so-called cannabinoid receptors. While to date, we know two types of cannabinoid receptors. Both of which belong to the class of G protein-coupled receptors. Both cannabinoid receptors modulate different ion channels. Furthermore, cannabinoid receptors influencing different signaling pathways within the cell.

location of cb1 and cb2 in the human body and brain
Location of Cannabinoids Receptors in the Human Body

Especially relevant, the following two cannabinoids receptors are known:

CB1 – The Cannabinoid Receptor 1

The CB1 receptor occurs mainly in nerve cells, in the brain. Same as in the central nervous system and related organs. For example, in the cerebellum or in the hippocampus. Therefore, the intake of THC effects psychoactivity. CBG or CBD, on the other hand, do not bind to CB1 receptors. While cannabidiol and cannabigerol have no psychoactive effect.  So you’re not getting “high”.

But also in the intestine CB1 receptors can be found. Consisting of 472 amino acids. They are responsible for mood swings in our body. Healthy appetite got improved. Also great for motor skills or the sensation of pain. Furthermore, they also affect our memory and sleep. All reasons to take cannabinoids especially for the treatment of chronic pain or depression.

CB2 – The Cannabinoid Receptor 2

Unlike CB1, CB2 receptors mainly affect our immune system. In addition, on cells as well, which are involved in bone formation and degradation. Also, G protein is coupled.

CB2 receptors consist of 360 amino acids. Much as they can be found almost throughout the body. Their functions are still poorly understood. It seems that cytokine is released. Probably one of the reasons why CB2 affects our immune system. Same as the gastrointestinal system and related organs. Therefore, medical doctors assume, that the main function of CB2 receptors is to regulate inflammation.

Finally, there are also indications that other cannabinoid receptors exist. However, the scientific proof for this is still pending.

Cannabinoids and their Effects on the Body

cb1 and cb2 structure of cannabinoids receptors
the structure of CB1 and CB2 receptors

As already mentioned, little is known about the significance and functions of endocannabinoid systems. While the distribution of the receptors already indicates a number of possible functions. Hense the good effects on the human body. Yet the scientifically substantiated evidence is still rare.

The most important effects in the body include:

Increased Learning Capability – Endogenous activation of the CB1 receptor promotes associative learning in the cerebellum.

Relieving depression – CB1 receptors clear negative memories.

Reduction of anxiety – In a study at the Max Planck Institute, CB1 receptors showed the loss of negative experiences.

Other initial findings were made in pain relief and sleep disorders. Same as for appetite and temperature control. Cannabinoids already showing huge benefits in cancer therapies.

Studies with partly conflicting results have been performed in patients with movement disorders. Same as with dystonia or Tourette’s syndrome. Almost the same results with Huntington’s disease and multiple sclerosis. Always positive are relevant client testimonials.

Is THC the “bad” and CBD the “good” Cannabinoid?

how cannabinoids receptors work cb1
THC is most important to treat the CB1 receptor

As described above, THC is a very useful cannabinoid. Below you will find some scientific studies scientific studies about THC. They prove that tetrahydrocannabinol is of big help. Cancer or multiple sclerosis treatments do need THC. Furthermore, it is a fact, that the only “bad” thing about THC is, that it can make you high. On the other hand, cannabinoids like CBD or CBG does reduce the psychoactive effect of THC.

As a matter of mother nature, there is no 0% THC product. Unless you take genetically manipulated pharmaceuticals. Consequently, cannabis manufacturers like Mountain Grades, try to breed high CBD and CBG strains. As a result, high CBG strains automatically downgrade the THC content.

Seems like it’s talking more years until the world accepts the medicinal need of THC as well. THC is still demonized. Maybe we just face the fact, that alcohol is a drug as well. Especially relevant: What about other natural drug resources like mushrooms or berries? So why are they not prohibited as THC? Seems like our society must think about legalization. If we could legally use THC, the most important cannabinoid, we could process even better products.

Scientific facts to promote our bodily functions through cannabinoids

cannabinoids killing cancer tumors diagram
how cannabinoids killing cancer tumor cells
FOPH Switzerland – Medical use of cannabis

„79 clinical trials involving more than 6,000 participants were statistically evaluated. The study concludes that intake of cannabis is associated with relief of symptoms. For the efficacy of cannabis products in the treatment of chronic or cancer pain and muscle spasms due to multiple sclerosis. Also in cases of nausea as a side effect of chemotherapy, weight loss of AIDS, sleep disorders and Tourette’s syndrome.”

The Swiss Federal Office of Public Health has investigated the medical use of cannabis. Cannabis showed especially great effects in chronic or cancer-related pain.

Link to the study!

Stony Brook University – CBD against epilepsy

„CBD can help reduce seizures and could be a potential new drug for the treatment of pediatric therapy-resistant epilepsy.”

Researchers identified fatty acid binding proteins (FABPs) in which CBD (cannabidiol) is considered intracellular.

Link to the study!

American Society of Pharmacology – CBD a very effective anti-tumor

„Studies have proven scientifically that CBD is a very effective antitumor agent for brain tumors.”

A study published in the journal of Pharmacology on Experimental Therapeutics showed, the viability of tumor cells with CBD significantly reduced. Therefore, CBD is a very effective antitumor agent.

Link to the article!

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